|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Amplification of Int-2 was detectable (7 of 9 cases) in 78% of the HPV-positive carcinomas, whereas no virus infection could be found in the five cases with amplified Hst-1 only.
|
11016685 |
2000 |
|
Tumor Initiation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
|
25329002 |
2014 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
To investigate whether growth, invasion and metastasis of endometrial cancer cells is associated with neovascularization, the expressions of fibroblast growth factor-1 (acidic FGF), -2 (basic FGF) and -4 (hst-1) mRNAs and FGF-2 in endometrial cancers and normal endometria as controls were determined by reverse transcription-polymerase chain reaction-Southern blot and ELISA, respectively, and the relationships between their expressions and histological grades, grades of myometrial invasion or clinical stages of endometrial cancers were analyzed.
|
8685603 |
1996 |
|
Thrombocytopenia
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Intraperitoneal injection of a replication-deficient adenovirus containing the HST-1 (FGF-4) gene (Adex1HST-1) increased peripheral platelet counts in mice, and also effectively prevented experimentally induced thrombocytopenia.
|
10557081 |
1999 |
|
Thrombocytopenia
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
A single Adex1HST-1 injection caused continuously increased levels of serum HST-1 protein for at least 30 d and increased the count of large megakaryocytes in bone marrow, which specifically recovered platelet counts and more efficiently diminished the extent and duration of thrombocytopenia than any other reported cytokine or any combination of cytokines so far.
|
7635948 |
1995 |
|
testicular nonseminoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A significant association between tumor stage and hst-1 expression in the nonseminoma group was found (P = 0.0002, chi 2 test).
|
1706218 |
1991 |
|
Teratocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differentiation associated modulation of K-FGF expression in a human teratocarcinoma cell line and in primary germ cell tumours.
|
2009969 |
1991 |
|
Stomach Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
More importantly, HST-1 down-regulated TNF-α and the TNF-α-mediated activation of NF-κB and JNK/MAPK pathways that are the key determinants in the IND-gastropathy.
|
31215272 |
2019 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The hst gene was originally identified as a transforming gene in DNAs from human stomach cancers and from a noncancerous portion of stomach mucosa by DNA-mediated transfection assay using NIH3T3 cells. cDNA clones of hst were isolated from the cDNA library constructed from poly(A)+ RNA of a secondary transformant induced by the DNA from a stomach cancer.
|
2953031 |
1987 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Sequence analysis revealed the presence of the human oncogene hst (fgf4) at a distance of approximately 9kb from the myeov gene in our MA-T1a1 tertiary transfectants.
|
17390055 |
2007 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, cosmid clones containing the hst gene were isolated directly from normal human leukocyte DNA and from T361-2nd-1 cells, a secondary transformant of NIH3T3 cells induced by transfection of DNA from a stomach cancer.
|
2895649 |
1988 |
|
Stable angina
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on promising preclinical animal data, a series of four randomized placebo-controlled clinical trials have been conducted to determine the safety and efficacy of local delivery of fibroblast growth factor 4 with the use of adenovirus-vector-mediated gene transfer to induce myocardial angio-/arteriogenesis in patients with stable angina.
|
18555186 |
2008 |
|
Stable angina
|
0.020 |
Biomarker
|
disease |
BEFREE |
Seventy-nine patients with chronic stable angina Canadian Cardiovascular Society class 2 or 3 underwent double-blind randomization (1:3) to placebo (n=19) or Ad5-FGF4 (n=60).
|
11901038 |
2002 |
|
Squamous cell carcinoma of esophagus
|
0.040 |
Biomarker
|
disease |
BEFREE |
These results suggest that int-2/hst-1 coamplification is a new biological indicator of prognosis and distant organ metastasis in patients with esophageal squamous cell carcinoma.
|
1997190 |
1991 |
|
Squamous cell carcinoma of esophagus
|
0.040 |
Biomarker
|
disease |
BEFREE |
In the present study, the anti-cancer effects of GSE were demonstrated in three ESCC cell lines (HKESC-1, HKESC-2 and SLMT-1) by MTS and anchorage-independent clongen-icity assays, expression studies on oncogenes at 11q13 (CCND1, INT2, FGF4 and EMS1) and real-time quantitative telomeric repeat amplification protocol assay to show the inhibitory effect of GSE on telomerase in ESCC.
|
17487429 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.040 |
Biomarker
|
disease |
BEFREE |
Therefore, FGF4 amplification in combination with clinical stage could be used as a relatively accurate predictor for the 5-year probability of death and recurrence for ESCC patients.
|
29936056 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Amplification of 11q13.3 (FGF4) and deletion of 9p21.3 (CDKN2A) were found to be recurrent in all 38 superficial ESCCs analyzed.
|
27974698 |
2017 |
|
Squamous cell carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The hst-1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes.
|
3136110 |
1988 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma.
|
1997190 |
1991 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Inhibition by 5-fluorouracil of ERCC1 and gamma-glutamylcysteine synthetase messenger RNA expression in a cisplatin-resistant HST-1 human squamous carcinoma cell line.
|
9268987 |
1997 |
|
Squamous cell carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
There was no evidence of a correlation between hst-1 gene amplification and several prognostic factors other than the histological type; hst-1 gene amplification was more common in well differentiated squamous cell carcinoma.
|
8010723 |
1994 |
|
Soft Tissue Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, Kim and co-workers show that a chimeric protein, EWS-Oct-4, transcriptionally activates fibroblast growth factor-4 (FGF-4) and triggers a downstream cascade of oncogenic signalling pathways, thereby facilitating the initiation of human bone and soft tissue tumour development.
|
31400091 |
2019 |
|
Seminoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
There were significant differences in oncogene expression between seminomas and nonseminomas with c-kit being expressed in 24 of 30 (80%) seminomas but in only 3 of 40 (7%) nonseminomatous tumors (P = 0.0001, chi 2 test) and hst-1 being expressed in 24 of 38 (63%) nonseminomas but only 1 of 24 (4%) of seminomas (P = 0.0001, chi 2 test), demonstrating an inverse relationship in the expression pattern of these 2 oncogenes in human testicular germ cell tumors.
|
1706218 |
1991 |
|
Seminoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma.
|
21649665 |
2011 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Oct-3/4 can up-regulate fibroblast growth factor-4 and matrix metalloproteinase-2 (MMP-2), MMP-9, and MMP-13 production, which may contribute to tumor metastasis.
|
18676852 |
2008 |